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Evidence for OTUD-6B Participation in B Lymphocytes Cell Cycle After Cytokine Stimulation

Evidence for OTUD-6B Participation in B Lymphocytes Cell Cycle After Cytokine Stimulation

Zhongping Xu, Yufang Zheng, Yufei Zhu, Xiangyin Kong, Landian Hu

PLoS One. 2011 Jan 18;6(1):e14514.

PMID: 21267069

Abstract:

Deubiquitinating enzymes (DUBs) are important regulators of cell proliferation. Here we identified a functional deubiquitinating enzyme, ovarian tumor domain-containing 6B (OTUD-6B). Mutation of the conserved Cys residue abolished its deubiquitinating activity in vitro. Otud-6b expression was induced with cytokine stimulation in both mouse Ba/F3 cells and primary B lymphocytes followed a rapid decrease. This rapid decrease was partially facilitated by tristetraprolin (TTP) destabilization of Otud-6b mRNA through AU-rich motifs. Enforced expression of OTUD-6B in Ba/F3 cells could block cell proliferation by arresting cells in G1 phase. In addition, cyclin D2 level was down-regulated when OTUD-6B WT was overexpressed. Therefore, down-regulation of Otud-6b expression after prolonged cytokine stimulation may be required for cell proliferation in B lymphocytes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42415053	OTUD6B active human			Price

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