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Evidence That Rat Platelet Fibrinogen Molecules Lack the Gamma' Chain Variant Found in Plasma Fibrinogen Molecules

Evidence That Rat Platelet Fibrinogen Molecules Lack the Gamma' Chain Variant Found in Plasma Fibrinogen Molecules

G A Homandberg, J E Williams, D B Evans, M W Mosesson

Thromb Res. 1985 Jul 15;39(2):203-9.

PMID: 3895563

Abstract:

Heterogeneity of rat plasma fibrinogen gamma chains (gamma A, gamma') is due to differential splicing of the primary mRNA transcript. Human gamma' chains, which amount to 7% of the total gamma chain population of plasma (hepatic) fibrinogen, are not detectable in fibrinogen isolated from platelets. In this investigation, we extended our studies to rats and found that gamma' chains, representing 30% of the rat plasma gamma chain population, are not detectable in their platelet fibrinogen.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9001325-B	Fibrinogen from rat plasma		9001-32-5	Price

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