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Excitation of Triplet States of Hypericin in Water Mediated by Hydrotropic Cromolyn Sodium Salt

Excitation of Triplet States of Hypericin in Water Mediated by Hydrotropic Cromolyn Sodium Salt

Peter Keša, Daniel Jancura, Júlia Kudláčová, Eva Valušová, Marián Antalík

Spectrochim Acta A Mol Biomol Spectrosc. 2018 Mar 15;193:185-191.

PMID: 29241053

Abstract:

Hypericin (Hyp) is a hydrophobic pigment found in plants of the genus Hypericum which exhibits low levels of solubility in water. This work shows that the solubility of Hyp can be significantly increased through the addition of cromolyn disodium salt (DSCG). Performed studies using UV-VIS absorption and fluorescence spectroscopies demonstrate that Hyp remains in a predominantly biologically photodynamic active monomeric form in the presence of DSCG at concentrations ranging from 4.6×10-3 to 1.2×10-1mol·L-1. The low association constant between Hyp and DSCG (Ka=71.7±2M-1), and the polarity value of 0.3 determined for Hyp in a DSCG-water solution, lead to a suggestion that the monomerization of Hyp in aqueous solution can be explained as a result of the hydrotropic effect of DSCG. This hydrotropic effect is most likely a result of interactions between two relative rigid aromatic rings of DSCG and a delocalized charge on the surface of the Hyp molecule. The triplet-triplet (T-T) electronic transition observed in is Hyp in the presence of DSCG suggests a possible production of reactive oxygen species once Hyp is irradiated with visible light in a DSCG aqueous solution.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP15826376-B	Cromolyn sodium salt		15826-37-6	Price

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