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Exercise Attenuates Levodopa-Induced Dyskinesia in 6-hydroxydopamine-lesioned Mice

Exercise Attenuates Levodopa-Induced Dyskinesia in 6-hydroxydopamine-lesioned Mice

A S Aguiar Jr, E L G Moreira, A A Hoeller, P A Oliveira, F M Córdova, V Glaser, R Walz, R A Cunha, R B Leal, A Latini, R D S Prediger

Neuroscience. 2013 Jul 23;243:46-53.

PMID: 23558088

Abstract:

L-DOPA alleviates the motor symptoms of Parkinson's disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this L-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with L-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercise (running wheel) during 2 weeks. Exercise drastically prevented the development of LID, and its associated aberrant striatal signaling, namely the hyperphosphorylation of dopamine and cAMP-regulated phosphoprotein 32 kDa protein and c-Fos expression. Our results indicate that exercise can partially prevent the development of LID through the normalization of striatopallidal dopaminergic signaling.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP28094157	6-Hydroxydopamine hydrochloride		28094-15-7	Price

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