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Exosomes Derived From Human Umbilical Cord Blood Mesenchymal Stem Cells Stimulates Rejuvenation of Human Skin

Exosomes Derived From Human Umbilical Cord Blood Mesenchymal Stem Cells Stimulates Rejuvenation of Human Skin

Yoon-Jin Kim, Sae Mi Yoo, Hwan Hee Park, Hye Jin Lim, Yu-Lee Kim, Seunghee Lee, Kwang-Won Seo, Kyung-Sun Kang

Biochem Biophys Res Commun. 2017 Nov 18;493(2):1102-1108.

PMID: 28919421

Abstract:

Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) play an important role in cutaneous wound healing, and recent studies suggested that MSC-derived exosomes activate several signaling pathways, which are conducive in wound healing and cell growth. In this study, we investigated the roles of exosomes that are derived from USC-CM (USC-CM Exos) in cutaneous collagen synthesis and permeation. We found that USC-CM has various growth factors associated with skin rejuvenation. Our in vitro results showed that USC-CM Exos integrate in Human Dermal Fibroblasts (HDFs) and consequently promote cell migration and collagen synthesis of HDFs. Moreover, we evaluated skin permeation of USC-CM Exos by using human skin tissues. Results showed that Exo-Green labeled USC-CM Exos approached the outermost layer of the epidermis after 3 h and gradually approached the epidermis after 18 h. Moreover, increased expressions of Collagen I and Elastin were found after 3 days of treatment on human skin. The results showed that USC-CM Exos is absorbed into human skin, it promotes Collagen I and Elastin synthesis in the skin, which are essential to skin rejuvenation and shows the potential of USC-CM integration with the cosmetics or therapeutics.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9007583-B	Elastin from human skin		9007-58-3	Price

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