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Experimental and Simulation Studies of strontium/fluoride-codoped Hydroxyapatite Nanoparticles With Osteogenic and Antibacterial Activities

Qun Wang, Pengfei Li, Pengfei Tang, Xiang Ge, Fuzeng Ren, Cancan Zhao, Ju Fang, Kefeng Wang, Liming Fang, Yan Li, Chongyun Bao, Xiong Lu, Ke Duan

Colloids Surf B Biointerfaces. 2019 Oct 1;182:110359.

PMID: 31352253

Abstract:

Multiple ions codoping may effectively modulate physicochemical and biological properties of hydroxyapatite (HA) for diverse biomedical applications. This study synthesized strontium (Sr)-, fluorine (F)- doped, and Sr/F-codoped HA nanoparticles by a hydrothermal method, and investigated the effect of ion doping on characteristics of HA, including crystallinity, crystal size, lattice parameters, and substitution sites by experiments and simulation with density functional theory (DFT) methods. It was found that, Sr doping increased the lattice parameters of HA whereas F doping decreased these parameters. Additionally, F doping enhanced the structural stability of the Sr-doped HA. F doping created excellent antibacterial properties to effectively inhibit growth of Streptococcus mutans. An appropriate Sr doping level endowed HA with optimum osteogenic ability to promote osteoblastic differentiation of bone marrow stem cells. These suggest that, Sr/F codoping is an effective approach to synthesizing HA-based materials with both antibacterial and osteogenic properties. More broadly, HA nanomaterials with specific characteristics may be designed for meeting diverse requirements from biomedical applications.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP7783484 Strontium fluoride Strontium fluoride 7783-48-4 Price
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