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[Experimental Study of Cellular Response on the Intraocular Lens Surface in Terms of the Presence and Distribution of Fibronectin]

[Experimental Study of Cellular Response on the Intraocular Lens Surface in Terms of the Presence and Distribution of Fibronectin]

R Kanagawa, S Saika, K Miyamoto, S Ohmi, M Tamura, T Nakao

Nippon Ganka Gakkai Zasshi. 1990 Jun;94(6):549-52.

PMID: 2403038

Abstract:

An immunohistochemical study was performed to observe cellular proliferation on the surface of implanted intraocular lenses (IOLs) in rabbit eyes. Rabbits were killed 3-28 days postoperatively. The removed IOLs were examined by an immunoperoxidase staining method using anti-fibronectin antibodies. The immunoreactivity for fibronectin was detected in macrophages and multinucleated giant cells attached to the IOL surface. Prominent stains were observed in these cells 1 week after the operation, and staining for fibronectin was less intense in the specimens 2 and 4 weeks after implantation. Fibronectin is produced by macrophages and multinucleated giant cells on the IOL surface, and might play important role in cellular adhesion and motility. Fibronectin immunoreactivity decreased with time and it may be related to cellular activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4241216	Anti-Fibronectin antibody produced in rabbit			Price

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