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[Experimental Study of the Anabolic Activity of 6-ketoderivatives of Certain Natural Sapogenins]

V N Syrov, A G Kurmukov

Farmakol Toksikol. Sep-Oct 1976;39(5):631-5.

PMID: 1028596

Abstract:

It is shown that 6-ketoderivatives of natural sapogenins, viz. agigenin, diosgenin and alliogenin, display the anabolic activity and do not manifest any androgenic properties. The compoud IV/(25 R)-5alpha-spirostan-2alpha, 3beta, 5alpha-triol-6-OH/produces an accelerated gain of weight in rats, and also an increase in the weight of the liver, heart, kidneys, musculus tibiliasis anterior and augments the total amount of protein therein. All of the above-mentioned changes become more pronounced with the study substance introduced to young animals. Castration of sexually immature rats greatly mitigates the anabolic effect of the compound IV.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP55332768 Agigenin Agigenin 55332-76-8 Price
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