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Exploring Optimized Methoxy Poly(ethylene glycol)-block-poly(ε-caprolactone) Crystalline Cored Micelles in Anti-Glaucoma Pharmacotherapy

Exploring Optimized Methoxy Poly(ethylene glycol)-block-poly(ε-caprolactone) Crystalline Cored Micelles in Anti-Glaucoma Pharmacotherapy

Enas Elmowafy, Heba Gad, Francesca Biondo, Luca Casettari, Mahmoud E Soliman

Int J Pharm. 2019 Jul 20;566:573-584.

PMID: 31176850

Abstract:

Methoxy-poly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG-PCL) polymeric micelles (PMs) open a promising avenue through which ocular drug delivery with superior efficacy and tolerability can be potentially obtained. Methazolamide (MTZ) is an anti-glaucoma drug exhibiting poor corneal penetration, making it an ideal candidate for new polymeric micellar systems. MTZ-PMs were prepared using the thin film hydration procedure and optimized using a Design of Experiment (DoE) approach. In vitro drug release, thermal analyses and FT-IR characterization were also evaluated. MTT assay and histopathological assessment were carried out to verify ocular tolerability as well as Draize irritancy test. In vivo studies were conducted on rabbits to evaluate anti-glaucoma activity in a glucocorticoid-induced glaucoma model. The results showed successful entrapment of MTZ inside PMs matrix as reflected by the complete vanishing of drug melting peak in DSC thermogram and the possible formation of hydrogen bonding between MTZ and mPEG-PCL copolymer in FT-IR spectrum. The selected formula exhibited a particle size of 60 nm, entrapment efficiency of 93% and discrete spherical particles. Moreover, sustained release of MTZ, cellular and tissue biocompatibility and marked anti-glaucoma efficacy, as compared to MTZ solution, were realized. The combined results show that PMs could potentiate the therapeutic outcome of nanotechnology ocular drug delivery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74322	Methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)			Price
LS74342	Poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone)			Price

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