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Exposure of Candida to P-Anisaldehyde Inhibits Its Growth and Ergosterol Biosynthesis

Exposure of Candida to P-Anisaldehyde Inhibits Its Growth and Ergosterol Biosynthesis

Sheikh Shreaz, Rimple Bhatia, Neelofar Khan, Sumathi Muralidhar, Seemi F Basir, Nikhat Manzoor, Luqman Ahmad Khan

J Gen Appl Microbiol. 2011;57(3):129-36.

PMID: 21817824

Abstract:

p-Anisaldehyde (4-methoxybenzaldehyde), an extract from Pimpinella anisum seeds, is a very common digestive herb of north India. Antifungal activity of p-anisaldehyde was investigated on 10 fluconazole-resistant and 5 fluconazole-sensitive Candida strains. Minimum inhibitory concentrations (MIC(90)) ranged from 250 µg/ml to 600 µg/ml for both sensitive and resistant strains. Ergosterol content was drastically reduced by p-anisaldehyde-62% in sensitive and 66% in resistant strains-but did not corelate well with MIC(90) values. It appears that p-anisaldehyde exerts its antifungal effect by decreasing NADPH routed through up-regulation of putative aryl-alcohol dehydrogenases. Cellular toxicity of p-anisaldehyde against H9c2 rat cardiac myoblasts was less than 20% at the highest MIC value. These findings encourage further development of p-anisaldehyde.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP123115	p-Anisaldehyde		123-11-5	Price

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