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Exposure to Naphthalene Induces Naphthyl-Keratin Adducts in Human Epidermis in Vitro and in Vivo

Exposure to Naphthalene Induces Naphthyl-Keratin Adducts in Human Epidermis in Vitro and in Vivo

Juei-Chuan C Kang-Sickel, Vandy P Stober, John E French, Leena A Nylander-French

Biomarkers. 2010 Sep;15(6):488-97.

PMID: 20500019

Abstract:

We observed naphthyl-keratin adducts and dose-related metabolic enzyme induction at the mRNA level in reconstructed human epidermis in vitro after exposure to naphthalene. Immunofluorescence detection of 2-naphthyl-keratin-1 adducts confirmed the metabolism of naphthalene and adduction of keratin. We also observed naphthyl-keratin adducts in dermal tape-strip samples collected from naphthalene-exposed workers at levels ranging from 0.004 to 6.104 pmol adduct microg(-1) keratin. We have demonstrated the ability of the human skin to metabolize naphthalene and to form naphthyl-keratin adducts both in vitro and in vivo. The results indicate the potential use of keratin adducts as biomarkers of dermal exposure.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP68238357	Keratin from human epidermis		68238-35-7	Price

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