Home
Resources
Publications
Expression of Flk-1 and Cyclin D2 mRNA in the Myocardium of Rats With Doxorubicin-Induced Cardiomyopathy and After Treatment With Betulonic Acid Amide

Expression of Flk-1 and Cyclin D2 mRNA in the Myocardium of Rats With Doxorubicin-Induced Cardiomyopathy and After Treatment With Betulonic Acid Amide

M M Mzhelskaya, M G Klinnikova, E V Koldysheva, E L Lushnikova

Bull Exp Biol Med. 2017 Oct;163(6):809-813.

PMID: 29063324

Abstract:

The expression of VEGFR2 (Flk-1, according to immunohistochemistry) and of cyclin D2 mRNA (according to real-time PCR) in the myocardium of rats is studied in doxorubicin-induced cardiomyopathy and in response to betulonic acid amide. Doxorubicin alone and in combination with betulonic acid amide causes after 3 days a manifest reduction of cyclin D2 mRNA expression (by 38 and 63%, respectively), while injection of betulonic acid amide alone causes a 23-fold increase of cyclin D2 mRNA expression. An increase of cyclin D2 mRNA expression has been detected in all experimental groups after 14 days of experiment, the most pronounced in response to betulonic acid amide (63 times). The expression of Flk-1 in cardiomyocytes increases significantly in response to both chemical agents starting from day 3 of experiment. These results indicate that doxorubicin and betulonic acid amide induce cytoprotective reactions in the myocardium, first at the intracellular, then at the cellular levels.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4481623	Betulonic acid		4481-62-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: