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Expression of Macrophage Inflammatory protein-1alpha (MIP-1alpha) in Human Endometrium Throughout the Menstrual Cycle

Expression of Macrophage Inflammatory protein-1alpha (MIP-1alpha) in Human Endometrium Throughout the Menstrual Cycle

M Akiyama, H Okabe, K Takakura, Y Fujiyama, Y Noda

Br J Obstet Gynaecol. 1999 Jul;106(7):725-30.

PMID: 10428531

Abstract:

Objective:
To investigate the distribution and the role of macrophage inflammatory protein-1alpha (MIP-1alpha) in human endometrium during cyclic changes.
Setting:
Department of Obstetrics and Gynaecology, Shiga University of Medical Science and University Hospital.
Materials:
Eighteen endometrial tissue specimens surgically resected or biopsied from women with normal menstrual cycles, without hormonal disorder or endometrial diseases.
Methods:
By immunohistochemistry, using monoclonal antibodies (lambda delta 78 for MIP-1alpha and CR3/43 for human leukocyte antigen-DR (HLA-DR)).
Results:
Immunoreactivity for anti-MIP-1alpha was distributed diffusely in epithelial cells throughout the proliferative and secretory phases but was absent during menstruation due to degenerative or necrotic changes. HLA-DR was expressed in epithelial cells only in the late secretory phase and was not expressed in stromal cells.
Conclusion:
Immunohistochemical analysis showed the presence of MIP-1alpha in the endometrial epithelium. Expression of HLA-DR in epithelial cells was observed only in the late secretory phase, suggesting that accumulation of MIP-1alpha in epithelium occurred by self production and not via a receptor mediated pathway. MIP-1alpha was released from the denuded epithelium during menstruation and appeared to contribute to the accumulation of monocytes/macrophages into the endometrial cavity. MIP-1alpha has a number of biological effects other than monocytic chemotaxis, and some of these effects may be exerted in the endometrial tissue.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248673	MIP-1alpha human			Price

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