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Expression of Macrophage Inflammatory protein-3beta in Human Endometrium Throughout the Menstrual Cycle

Expression of Macrophage Inflammatory protein-3beta in Human Endometrium Throughout the Menstrual Cycle

Nobue Daikoku, Kotaro Kitaya, Takeshi Nakayama, Shinji Fushiki, Hideo Honjo

Fertil Steril. 2004 Mar;81 Suppl 1:876-81.

PMID: 15019823

Abstract:

Objective:
To determine the expression of macrophage inhibitory protein-3beta (MIP-3beta), a potential chemoattractant for endometrial natural killer (NK) cells, in the human endometrium.
Design:
An experimental study.
Setting:
University department of obstetrics and gynecology.
Patient(s):
Thirty-seven fertile women with regular menstrual cycles and nonpathological endometrium, undergoing hysterectomy.
Intervention(s):
Endometrium was obtained from operative samples.
Main outcome measure(s):
Paraffin-embedded endometrium was immunostained to determine the localization of MIP-3beta. The number of NK cells was counted in 10 nonoverlapping stromal areas. The MIP-3beta concentration in the homogenized endometrium was determined by ELISA.
Result(s):
Immunoreactivity for MIP-3beta was observed in the surface epithelia, glandular epithelia, and stroma with some menstrual cycle-dependent fluctuation. The MIP-3beta concentration was significantly higher in the late secretory phase than in the other phases. It showed a trend toward correlation with the number of endometrial NK cells.
Conclusion(s):
MIP-3beta was expressed in the human endometrium, but our results could not strongly support the hypothesis that MIP-3beta is a potential chemoattractant for endometrial NK cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413128	MIP-3beta human			Price

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