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Expression Patterns of Male Germ Cell Markers in Cryptorchid Pig Testes

Expression Patterns of Male Germ Cell Markers in Cryptorchid Pig Testes

Hyun-Jung Park, Hyuk Song, Jae-Seok Woo, Hak-Jae Chung, Jin-Ki Park, Kwang-Hyun Cho, Joon Mo Yeo, Won-Young Lee

Acta Histochem. 2019 Oct;121(7):784-790.

PMID: 31324385

Abstract:

Male germ cell apoptosis has been described in heat-damaged testes by cryptorchidism. In the present study, wild type pig testes were compared with cryptorchid testes via histological and immunohistological analyses. Spermatozoa were not detected in two cryptorchid testes and the diameters of seminiferous tubules were significantly reduced in cryptorchid pig testes compared with wild type pig testes. Cells expressing marker genes for undifferentiated spermatogonia, such as protein gene product 9.5 was significantly decreased in cryptochid pig testes. In addition, the numbers of cells expressing DEAD-box polypeptide 4 (VASA), synaptonemal complex protein 3, protamine, and acrosin (a biomarker of spermatocyte, spermatid, and spermatozoa) were significantly reduced in cryptochid pig testes. However, the number of vimentin-expressing Sertoli cells was not changed or was significantly increased in cryptorchid pig testes. This result indicates that male germ cells are specifically damaged by heat in cryptorchid pig testes and not Sertoli cells. These findings will facilitate the further study of spermatogenesis and the specific mechanisms by which cryptorchidism causes male infertility.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP61417467	Deamino-Tyr-β-Ala-secretin, pig		61417-46-7	Price

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