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Fabrication of magnesium/zinc-metal Organic Framework on Titanium Implants to Inhibit Bacterial Infection and Promote Bone Regeneration

Fabrication of magnesium/zinc-metal Organic Framework on Titanium Implants to Inhibit Bacterial Infection and Promote Bone Regeneration

Xinkun Shen, Yangyang Zhang, Pingping Ma, Linawati Sutrisno, Zhong Luo, Yan Hu, Yonglin Yu, Bailong Tao, Chuanqiang Li, Kaiyong Cai

Biomaterials. 2019 Aug;212:1-16.

PMID: 31100479

Abstract:

The residual bacteria in the second revision surgery caused by infection would further lead to the failure of the implantation. Pathogenic bacteria adhesion to an implant surface not only interfere the functions of bone-formation related cells, but also activate the host immune system, thus resulting in inflammation and osteogenesis inhibition. Thus, to fabricate multifunctional (antibacterial, anti-inflammation and pro-osteogenesis) titanium implants is essential to address this issue. In this work, hybrid magnesium/zinc-metal organic framework (Mg/Zn-MOF74) coating was constructed on alkali-heat treated titanium (AT) surface. The hybrid Mg/Zn-MOF74 coating displayed good stability and its stability was related to the content of Zn2+. The MOF74-modified samples were sensitive to bacterial acid microenvironment and displayed strong antibacterial ability against both Escherichia coli and Staphylococcus aureus due to the degradation of MOF74 coating, leading to alkaline microenvironment (about pH 8.0) and degradation products (2,5-dihydroxyterephthalic acid and Zn2+). The coating also showed good early anti-inflammatory property to native Ti substrates. In vivo results further verified that AT-Mg/Zn3 implants had high antibacterial and anti-inflammatory properties at early stage of implantation, and greatly improved new bone formation around implants both at non-infected and infected femur sites.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP610924	2,5-Dihydroxyterephthalic acid		610-92-4	Price

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