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Fabrication of Novel Avermectin Nanoemulsion Using a Polyurethane Emulsifier With Cleavable Disulfide Bonds

Wenxun Guan, Wenxiang Zhang, Liming Tang, Yan Wang, Haixin Cui

J Agric Food Chem. 2018 Jul 5;66(26):6569-6577.

PMID: 28700229

Abstract:

In this study, a polyurethane emulsifer with various functional groups was prepared from isophorone diisocyanate, avermectin, 2,2-dimethylol propionic acid, and bis(2-hydroxyethyl) disulfide. The chemical structure of the polymer was confirmed by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, and element analysis. The polymer exhibited adequate emulsification ability for avermectin after neutralization with triethylamine. A satisfaying nanoemulsion was obtained, in which avermectin was encapsulated in nanoparticles with 50 wt % drug loading, low organic solvent content, and high stability under dilution and centrifuging treatment in addition to low surface tension, high affinity to crop leaf, and improved avermectin photostability. The resulting nanoparticles showed degradability in the presence of dl-dithiothreitol or inside the insect as a result of the disulfide bonds, promoting the release of avermectin. As a result, the avermectin nanoparticles showed higher insecticidal ability compared to both the avermectin nanoparticles without a disulfide group and the avermectin emulsifiable concentrate.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP3483123 DL-Dithiothreitol DL-Dithiothreitol 3483-12-3 Price
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