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Facile Preparation of Beta-Fluoro Amines by the Reaction of Aziridines With Potassium Fluoride Dihydrate in the Presence of Bu4NHSO4

Ren-Hua Fan, Yong-Gui Zhou, Wan-Xuan Zhang, Xue-Long Hou, Li-Xin Dai

J Org Chem. 2004 Jan 23;69(2):335-8.

PMID: 14725444

Abstract:

Potassium fluoride combined with tetrabutylammonium bisulfate is an efficient reagent to convert a variety of aziridines derived from cyclic and acyclic alkenes to beta-fluoro amine derivatives in high yield.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP32503278 Tetrabutylammonium bisulfate Tetrabutylammonium bisulfate 32503-27-8 Price
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