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Facile Preparation of Gadolinium(iii) Chelates Functionalized Carbon Quantum Dot-Based Contrast Agent for Magnetic resonance/fluorescence Multimodal Imaging

Facile Preparation of Gadolinium(iii) Chelates Functionalized Carbon Quantum Dot-Based Contrast Agent for Magnetic resonance/fluorescence Multimodal Imaging

Xianyan Ren, Lihua Liu, Yu Li, Qin Dai, Ming Zhang, Xinli Jing

J Mater Chem B. 2014 Sep 14;2(34):5541-5549.

PMID: 32262187

Abstract:

Suffering from high inherent toxicity generated from heavy metals in semiconductor quantum dots and a complex preparation process, the medical application of conventional gadolinium(iii)/semiconductor quantum dot-based magnetic resonance/fluorescence multimodal imaging (MRI/FI) contrast agent has been limited. In this paper, a new kind of biocompatible carbon quantum dot functionalized by gadolinium(iii) chelates (named as Gd(iii)/CQDs) was obtained through one-step pyrolysis of gadopentetate monomeglumine, which provides simultaneously a carbon source and a gadolinium(iii) source. The Gd(iii)/CQDs show good magnetic resonance response and photoluminescence properties with longitudinal relaxation rate and quantum yield of 5.5-6.4 mM L-1 S-1 [Gd(iii)%, 0.5 mM] and 2.6-8.9%, respectively. The Gd(iii)/CQDs with diameters in the range of 2-3 nm can be well dispersed in deionized water, phosphate-buffered saline buffer solution or culture medium to form a stable dispersion, which with low cytotoxicity can penetrate into cells and show green fluorescence (excitation at 488 nm), presenting a great potential to be used as an MRI/FI contrast agent.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP92923574	Gadopentetate monomeglumine		92923-57-4	Price

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