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Facile Synthesis of Highly Functionalized Ethyltrifluoroborates

Gary A Molander, Wilma Febo-Ayala, Montserrat Ortega-Guerra

J Org Chem. 2008 Aug 1;73(15):6000-2.

PMID: 18588349

Abstract:

Organotrifluoroborates are generating increased interest because of their ease of preparation and purification and indefinite shelf life. Herein we report the preparation of organotrifluoroborates bearing functional groups that can be manipulated at different stages of the synthetic route, exploiting the inertness of their carbon-boron bonds. The alkylation of 2,2-dicyanoethyltrifluoroborate with a variety of electrophiles and of (EWG)2CH2 with potassium iodomethyltrifluoroborate resulted in di- and trisubstituted ethyltrifluoroborates in good to excellent yields.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP44248079 Potassium ethyltrifluoroborate Potassium ethyltrifluoroborate 44248-07-9 Price
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