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Fast Determination of Codeine, Orphenadrine, Promethazine, Scopolamine, Tramadol, and Paracetamol in Pharmaceutical Formulations by Capillary Electrophoresis

Fast Determination of Codeine, Orphenadrine, Promethazine, Scopolamine, Tramadol, and Paracetamol in Pharmaceutical Formulations by Capillary Electrophoresis

Rafael R Cunha, Michelle M A C Ribeiro, Rodrigo A A Muñoz, Eduardo M Richter

J Sep Sci. 2017 Apr;40(8):1815-1823.

PMID: 28217928

Abstract:

Paracetamol is an active ingredient commonly found in pharmaceutical formulations in combination with one of the following compounds: codeine, orphenadrine, promethazine, scopolamine, and tramadol. In this work, we propose a unique analytical method for determination of these active ingredients in pharmaceutical samples. The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection. The separation was achieved on a fused silica capillary (50 cm total length, 40 cm effective length, and 50 μm id) using an optimized background electrolyte composed of 20 mmol/L β-alanine/4 mmol/L sodium chloride/4 μmol/L sodium hydroxide (pH 9.6). Each sample can be analyzed in a single run (≤2 min) and the limits of detection were 2.5, 0.62, 0.63, 2.5, 15, and 1.6 μmol/L for scopolamine, tramadol, orphenadrine, promethazine, codeine, and paracetamol, respectively. Recovery values for spiked samples were between 94 and 104%.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4682364-A	Orphenadrine citrate salt		4682-36-4	Price

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