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FGF-21 as a Novel Metabolic Regulator

FGF-21 as a Novel Metabolic Regulator

Alexei Kharitonenkov, Tatiyana L Shiyanova, Anja Koester, Amy M Ford, Radmila Micanovic, Elizabeth J Galbreath, George E Sandusky, Lisa J Hammond, Julie S Moyers, Rebecca A Owens, Jesper Gromada, Joseph T Brozinick, etc.

J Clin Invest. 2005 Jun;115(6):1627-35.

PMID: 15902306

Abstract:

Diabetes mellitus is a major health concern, affecting more than 5% of the population. Here we describe a potential novel therapeutic agent for this disease, FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes. FGF-21-transgenic mice were viable and resistant to diet-induced obesity. Therapeutic administration of FGF-21 reduced plasma glucose and triglycerides to near normal levels in both ob/ob and db/db mice. These effects persisted for at least 24 hours following the cessation of FGF-21 administration. Importantly, FGF-21 did not induce mitogenicity, hypoglycemia, or weight gain at any dose tested in diabetic or healthy animals or when overexpressed in transgenic mice. Thus, we conclude that FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248670	FGF-21 human			Price

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