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FGF-4 Increases in Vitro Expansion Rate of Human Adult Bone Marrow-Derived Mesenchymal Stem Cells

FGF-4 Increases in Vitro Expansion Rate of Human Adult Bone Marrow-Derived Mesenchymal Stem Cells

Jordi Farré, Santiago Roura, Cristina Prat-Vidal, Carolina Soler-Botija, Anna Llach, Cristina E Molina, Leif Hove-Madsen, Jordi J Cairó, Francesc Gòdia, Ramon Bragós, Juan Cinca, Antoni Bayes-Genis

Growth Factors. 2007 Apr;25(2):71-6.

PMID: 17852409

Abstract:

Human bone marrow-derived mesenchymal stem cells (MSCs) exhibit limited in vitro growth. Fibroblast growth factors (FGFs) elicit a variety of biological responses, such as cell proliferation, differentiation and migration. FGF-4 represents one of the FGFs with the highest cell mitogenic activity. We studied the effect of FGF-4 on MSCs growth and pluripotency. MSCs duplication time (Td) was significantly reduced with FGF-4 compared to controls (2.2 +/- 0.2 vs. 4.1 +/- 0.2 days, respectively; p = 0.03) while BMP-2 and SCF-1 did not exert a significant growth effect. MSC expression of surface markers, differentiation into adipogenic and osteogenic lineages, and baseline expression of cardiomyogenic genes were unaffected by FGF-4. In summary, exogenous FGF-4 increases the rate at which MSC proliferate and has no significant effect on MSC pluripotency.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248661	FGF-4 human			Price

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