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Fiber-optic Fluorescence-Quenching Oxygen Partial Pressure Sensor Using Platinum Octaethylporphyrin

Fiber-optic Fluorescence-Quenching Oxygen Partial Pressure Sensor Using Platinum Octaethylporphyrin

John J Davenport, Michelle Hickey, Justin P Phillips, Panayiotis A Kyriacou

Appl Opt. 2016 Jul 20;55(21):5603-9.

PMID: 27463913

Abstract:

The development and bench testing of a fiber-optic oxygen sensor is described. The sensor is designed for measurement of tissue oxygen levels in the mucosa of the digestive tract. The materials and construction are optimized for insertion through the mouth for measurement in the lower esophagus. An oxygen-sensitive fluorescence-quenching film was applied as a solution of platinum octaethylporphyrin (PtOEP) poly(ethyl methacrylate) (PEMA) and dichloromethane and dip coated onto the distal tip of the fiber. The sensor was tested by comparing relative fluorescence when immersed in liquid water at 37°C, at a range of partial pressures (0-101 kPa). Maximum relative fluorescence at most oxygen concentrations was seen when the PtOEP concentration was 0.1 g.L^-1, four layers of coating solution were applied, and a fiber core radius of 600 μm was selected, giving a Stern-Volmer constant of 0.129 kPa^-1. The performance of the sensor is suitable for many in vivo applications, particularly mucosal measurements. It has sufficient sensitivity, is sterilizable, and is sufficiently flexible and robust for insertion via the mouth without damage to the probe or risk of harm to the patient.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP31248392	Platinum octaethylporphyrin		31248-39-2	Price

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