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Fibrin Sealant Derived From Human Plasma as a Scaffold for Bone Grafts Associated With Photobiomodulation Therapy

Fibrin Sealant Derived From Human Plasma as a Scaffold for Bone Grafts Associated With Photobiomodulation Therapy

Karina Torres Pomini, Daniela Vieira Buchaim, Jesus Carlos Andreo, Marcelie Priscila de Oliveira Rosso, Bruna Botteon Della Coletta, Íris Jasmin Santos German, Ana Carolina Cestari Biguetti, André Luis Shinohara, etc.

Int J Mol Sci. 2019 Apr 10;20(7):1761.

PMID: 30974743

Abstract:

Fibrin sealants derived from human blood can be used in tissue engineering to assist in the repair of bone defects. The objective of this study was to evaluate the support system formed by a xenograft fibrin sealant associated with photobiomodulation therapy of critical defects in rat calvaria. Thirty-six rats were divided into four groups: BC (n = 8), defect filled with blood clot; FSB (n = 10), filled with fibrin sealant and xenograft; BCPBMT (n = 8), blood clot and photobiomodulation; FSBPBMT (n = 10), fibrin sealant, xenograft, and photobiomodulation. The animals were killed after 14 and 42 days. In the histological and microtomographic analysis, new bone formation was observed in all groups, limited to the defect margins, and without complete wound closure. In the FSB group, bone formation increased between periods (4.3 ± 0.46 to 6.01 ± 0.32), yet with lower volume density when compared to the FSBPBMT (5.6 ± 0.45 to 10.64 ± 0.97) group. It was concluded that the support system formed by the xenograft fibrin sealant associated with the photobiomodulation therapy protocol had a positive effect on the bone repair process.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9001314	Fibrin from human plasma		9001-31-4	Price

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