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Fibrinopeptide A Binds Gly-Pro-Arg-Pro

Fibrinopeptide A Binds Gly-Pro-Arg-Pro

R S Root-Bernstein, F C Westall

Proc Natl Acad Sci U S A. 1984 Jul;81(14):4339-42.

PMID: 6589598

Abstract:

The tetrapeptide Gly-Pro-Arg-Pro inhibits fibrinogen aggregation, probably by binding to the same sites used during initiation of fibrin formation. The Gly-Pro-Arg-Pro binding sites have not yet been identified. However, their possible sequence and locations have been predicted on the basis of the amino acid pairing hypothesis. One of these predicted sites is on fibrinopeptide A. We report here that nuclear magnetic resonance studies indicate that Gly-Pro-Arg-Pro binds to fibrinopeptide A with a binding constant, K, of ca. 10(4) per mol. We also report results of 19 related peptide combinations used as controls.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP67869629	Gly-Pro-Arg-Pro		67869-62-9	Price

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