Home
Resources
Publications
Fibroin/peptide Co-Functionalized Calcium Titanate Nanorods Improve Osteoinductivity of Titanium via Mimicking Osteogenic Niche

Fibroin/peptide Co-Functionalized Calcium Titanate Nanorods Improve Osteoinductivity of Titanium via Mimicking Osteogenic Niche

Yimin Sun, Cheng Hu, Yuanyi Yang, Bin Dong, Yi Deng

Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109836.

PMID: 31349462

Abstract:

The surface-inspirable biomaterials have captured extensive attention in simulating microenvironments by mimicking nanoscale architectures and signal molecules in the extracellular matrix (ECM). To activate osteogenic differentiation through biomimetic nanostructures, osteoid-like calcium titanate nanorods (CT) were fabricated via anodization and hydrothermal treatment. SEM, EDS, and XPS were employed to confirm the morphology and chemical composition. The functional fibroin and peptide layers on CT (PFCT) were subsequently applied to provide binding sites and bioactive molecules for osteoblast growth and differentiation. The hydrophilicity obviously increased with the protein layers. PFCT presented enhanced cell viability with pronounced pseudopod extension and continuous proliferation. The osteogenic differentiation analysis revealed that the alkaline phosphatase expression improved in the early stage. The calcium nodes and the collagen secretion were also enhanced. Quantitative polymerase chain reaction assessment indicated that osteogenesis-related markers including ALP, Col1, and Runx2, were up-regulated. The in vitro results demonstrated that fibroin/peptide co-functionalized calcium titanate nanorods were efficient to stimulate osteoblasts and improve cell adhesion, proliferation, and differentiation. Therefore, the nanorods can create an osteogenic niche on titanium implants, which can be a promising modification strategy in bone tissue engineering application.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP12049502	Calcium titanate		12049-50-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: