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Final Height in Congenital Adrenal Hyperplasia: The Dilemma of Hypercortisolism Versus Hyperandrogenism

Final Height in Congenital Adrenal Hyperplasia: The Dilemma of Hypercortisolism Versus Hyperandrogenism

Giovana Vignoli Cordeiro, Ivani Novato Silva, Eugênio Marcos Andrade Goulart, Antônio José das Chagas, Cláudio Elias Kater

Arq Bras Endocrinol Metabol. 2013 Mar;57(2):126-31.

PMID: 23525290

Abstract:

Objective:
The purpose of this study was to identify factors that might interfere with reaching the final height in patients with 21-hydroxylase deficiency (21-OHD).
Subjects and methods:
Thirty-one patients with classical 21-OHD who reached their FH in our Institution were evaluated in order to compare the Z score for final height (FHZ) with: (1) the target height, (2) the standard height for the population, and (3) the hydrocortisone treatment schedule.
Results:
The FHZ of -2.13 ± 1.11 had a significant negative correlation with the hydrocortisone doses used throughout the period of study. Patients who reached FH within the normal population range were those who received lower doses of hydrocortisone, as compared to those whose FH remained below -2 SDS.
Conclusion:
We conclude that careful treatment adjustments have a major influence on growth of children with CAH, and that the dose range for hydrocortisone replacement that does not lead to side effects is relatively narrow. The better height outcome was achieved in 21-OHD patients who received lower doses of hydrocortisone.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1883737630	FHZ		1883737-63-0	Price

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