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Flow Photochemistry as a Tool for the Total Synthesis of (+)-Epigalcatin

Kamil Lisiecki, Zbigniew Czarnocki

Org Lett. 2018 Feb 2;20(3):605-607.

PMID: 29345466

Abstract:

The first total synthesis of (+)-epigalcatin was completed in a highly stereoselective manner starting from piperonal, 3,4-dimethylbenzaldehyde, and diethyl succinate. l-Prolinol was used as a chiral auxiliary. The crucial step in this procedure involves the construction of the cyclolignan framework by continuous-flow photocyclization of a chiral atropisomeric 1,2-bisbenzylidenesuccinate amide ester.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP123251 Diethyl succinate Diethyl succinate 123-25-1 Price
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