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Fluorescence in a Cryptococcoma Following Administration of 5-aminolevulinic Acid Hydrochloride (Gliolan)

Fluorescence in a Cryptococcoma Following Administration of 5-aminolevulinic Acid Hydrochloride (Gliolan)

Waldo Gerard Solis, Mitchell Hansen

BMJ Case Rep. 2017 Apr 11;2017:bcr2017219469.

PMID: 28400397

Abstract:

A 54-year-old man presented with two episodes of dysarthria and left facial droop. Both episodes resolved by the time of examination. MRI of the brain revealed a right frontotemporal, heterogeneously enhancing mass with surrounding vasogenic oedema, suggestive of a high-grade primary brain neoplasm. The patient was administered preoperative 5-aminolevulinic acid hydrochloride (Gliolan), and fluorescence-guided resection of the lesion was undertaken. Cryptococcus gattii infection was diagnosed from the specimen and the patient was given appropriate antifungal treatment. This is the first reported case of Gliolan-mediated fluorescence in a fungal abscess and highlights one of the potential pitfalls in fluorescence-guided surgery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5451092-B	5-Aminolevulinic acid hydrochloride		5451-09-2	Price

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