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Fluorescence Spectroscopic Insight Into the Supramolecular Interactions in DNA-Based Enantioselective Sulfoxidation

Fluorescence Spectroscopic Insight Into the Supramolecular Interactions in DNA-Based Enantioselective Sulfoxidation

Yu Cheng, Mingpan Cheng, Jingya Hao, Guoqing Jia, Can Li

Chembiochem. 2018 Oct 18;19(20):2233-2240.

PMID: 30070000

Abstract:

Interactions of copper(II)-bipyridine cofactors and thioanisole substrate with human telomeric G-quadruplex DNA were studied by UV/Vis absorption, circular dichroism, and fluorescence quenching titration. Three copper(II)-bipyridine complexes are equivalently anchored to the G-quadruplex scaffold at all five fluorescently labeled sites. Thioanisole interacts with the DNA architecture at both the second loop and 3' terminus in the absence or presence of copper(II)-bipyridine complexes. These nonspecificities in the weak interactions of CuII complexes and thioanisole with G-quadruplex might explain why DNA only affords a modest enantioselectivity in the oxidation of thioanisole. These findings provide insights toward the construction of highly enantioselective DNA-based catalysts.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP100685	Thioanisole		100-68-5	Price

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