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Fluoride-specific fluorescence/MRI Bimodal Probe Based on a Gadolinium(iii)-Flavone Complex: Synthesis, Mechanism and Bioimaging Application in Vivo

Fluoride-specific fluorescence/MRI Bimodal Probe Based on a Gadolinium(iii)-Flavone Complex: Synthesis, Mechanism and Bioimaging Application in Vivo

Yue Wang, Run Zhang, Renfeng Song, Ke Guo, Qingtao Meng, Huan Feng, Chunying Duan, Zhiqiang Zhang

J Mater Chem B. 2016 Dec 14;4(46):7379-7386.

PMID: 32263738

Abstract:

Molecular imaging is a powerful tool to visualize cellular processes and activity levels of biomarkers at the cellular and molecular level, in which a molecular probe is a prerequisite for the molecular imaging technique. The present work reports a bimodal probe for the fluorescence and magnetic resonance detection of fluoride ions (F-) in aqueous media and in vivo. The bimodal probe, EDTA-Gd-HF, was prepared by self-assembly of the EDTA-Gd complex with 3-hydroxyflavone (HF). In the system, HF plays the role of spectroscopic reporter and Gd(iii) serves as a MRI signal output unit as well as the fluoride ion binding site. Upon addition of fluoride ions into an aqueous solution of EDTA-Gd-HF, the replacement of one coordinated water molecule and then liberation of HF led to remarkable spectroscopic recovery and distinct changes to the longitudinal relaxivity (r1), by which fluorescence/MRI bimodal fluoride ion sensing was achieved. In vivo magnetic resonance imaging (MRI) in mice indicates that EDTA-Gd-HF can be potentially used in biomedical diagnosis and therapy fields.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13765269	Gadolinium(III) fluoride		13765-26-9	Price

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