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Fluorine-modified Bisbenzimide Derivative as a Molecular Probe for Bimodal and Simultaneous Detection of DNAs by (19)F NMR and Fluorescence

Takashi Sakamoto, Daisaku Hasegawa, Kenzo Fujimoto

Chem Commun (Camb). 2015 May 25;51(42):8749-52.

PMID: 25873342

Abstract:

3,5-Bis(trifluoromethyl)benzene modified bisbenzimide H 33258 was synthesized as a (19)F magnetic resonance-based DNA detection probe. The chemical shift and fluorescence of the probe were significantly changed by the addition of hairpin DNAs having an AATT sequence. The probe enables (19)F NMR/fluorescence bimodal detection of the model DNA double strands simultaneously.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP23491454-A bisBenzimide H 33258 bisBenzimide H 33258 23491-45-4 Price
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