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Fluoroquinolones Structural and Medicinal Developments (2013-2018): Where Are We Now?

Ghadeer A R Y Suaifan, Aya A M Mohammed

Bioorg Med Chem. 2019 Jul 15;27(14):3005-3060.

PMID: 31182257

Abstract:

Fluoroquinolones are considered one of the widely utilized antibiotics, specifically, with the recent development of newer generations such as moxifloxacin, delafloxacin and finafloxacin which possess a wider spectrum of activity and improved bioavailability. However, alarming increase in bacterial resistance reports worldwide incites medicinal chemists to employ guided-biologically-oriented-synthesis-strategies toward the modulation of quinolones derivatives activity. At present, quinolone scaffold diverse biological activities prompted the fortuitous discovery of novel antimicrobial and anticancer derivatives. Herein, the opponent arguments (2013-2015) regarding the structure activity relationships of fluoroquinolones' antibacterial, anticancer, antifungal activities are inscribed.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP209342405 Finafloxacin Finafloxacin 209342-40-5 Price
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