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Flurazepam Hydrochloride and Its Principal Metabolites: Behavioural Studies in the Monkey (Macaca Mulatta)

Flurazepam Hydrochloride and Its Principal Metabolites: Behavioural Studies in the Monkey (Macaca Mulatta)

C M Bradley, A N Nicholson

Psychopharmacology (Berl). 1984;82(4):395-9.

PMID: 6427834

Abstract:

Effects of flurazepam and its two principal metabolites, hydroxyethylflurazepam and desalkylflurazepam (0.5, 1.0, 3.0 and 10.0 mg/kg), were studied on a delayed differentiation task in the monkey. Flurazepam (10.0 mg/kg) and hydroxyethylflurazepam (3.0 and 10.0 mg/kg) decreased the number of correct responses and increased response latency; effects persisted to 4 h with the highest dose. Marked impairment of performance was observed with all doses of desalkylflurazepam and effects of 3.0 and 10.0 mg/kg persisted to 24 h. Evidence of a disinhibitory effect of desalkylflurazepam was demonstrated. The study would point to a consideration of both metabolites in the hypnotic effect and in the impairment of performance observed after acute ingestion of flurazepam in man.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1172185	Flurazepam hydrochloride		1172-18-5	Price

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