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Fluvoxamine Maleate Normalizes Striatal Neuronal Inflammatory Cytokine Activity in a Parkinsonian Rat Model Associated With Depression

Fluvoxamine Maleate Normalizes Striatal Neuronal Inflammatory Cytokine Activity in a Parkinsonian Rat Model Associated With Depression

Ernest Dallé, Willie M U Daniels, Musa V Mabandla

Behav Brain Res. 2017 Jan 1;316:189-196.

PMID: 27569183

Abstract:

Cytokine dysfunction is associated with both depression and Parkinson's disease (PD) pathophysiology. Inflammatory cytokines in neural and behavioral processes are involved in the production and/or maintenance of depression in PD. In this study we looked at how Fluvoxamine treatment regulates depressive-like signs, motor impairments and the expression of IL-1β, IL-6, TNF-α, TGF-β and IL-10 cytokines in the striatum of a stressed Parkinsonian rat model. Early maternal separation was used to model stress and depressive-like signs in rats. Maternally separated adult rats were treated with Fluvoxamine for 30days prior to 6-hydroxydopamine (6-OHDA) lesion. The sucrose preference test (SPT) and the limb-use asymmetry test (cylinder test) were used to evaluate anhedonia and motor impairments respectively. Lipid peroxidation and cytokine expression were measured in striatal tissue using ELISA and real-time PCR techniques respectively. Our results show that maternal separation resulted in anhedonia and exacerbated 6-OHDA lesion but Fluvoxamine treatment attenuated these effects. Lipid peroxidation, mRNA levels of IL-1β, IL-6 and TNF-α were down-regulated while IL-10 and TGF-β levels were up-regulated in the lesioned striatum of Fluvoxamine treated rats. This study shows that early treatment with Fluvoxamine may attenuate inflammation on injured striatal neurons by favoring anti-inflammatory cytokine expression while decreasing pro-inflammatory cytokine release in the brain. This suggests a role of Fluvoxamine as a potential therapeutic intervention targeting neuronal inflammation associated with PD.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP61718829-A	Fluvoxamine Maleate		61718-82-9	Price

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