Home
Resources
Publications
Folic Acid-Conjugated pH/temperature/redox Multi-Stimuli Responsive Polymer Microspheres for Delivery of Anti-Cancer Drug

Folic Acid-Conjugated pH/temperature/redox Multi-Stimuli Responsive Polymer Microspheres for Delivery of Anti-Cancer Drug

Rongrong Li, Fuli Feng, Yinsong Wang, Xiaoying Yang, Xinlin Yang, Victor C Yang

J Colloid Interface Sci. 2014 Sep 1;429:34-44.

PMID: 24935187

Abstract:

The folic acid (FA)-conjugated pH/temperature/redox multi-stimuli responsive poly(methacrylic acid-co-N,N-bis(acryloyl)cystamine/poly(N-isopropylacrylamide-co-glycidyl methacrylate-co-N,N-bis(acryloyl)cystamine) microspheres were prepared by a two-stage distillation-precipitation polymerization with subsequent surface modification with FA. The microspheres were characterized by transmission electron microscopy, dynamical light scattering, Fourier-transform infrared spectra, UV-vis spectra and elemental analysis. The degradation of the functional microspheres could be triggered by a reductive reagent, such as glutathione, due to presence of BAC crosslinker. The drug-loaded microspheres exhibited a pH/temperature/redox multi-stimuli responsive drug release character for doxorubicin hydrochloride as a model anti-cancer drug, which was efficiently loaded into the microspheres with a high loading capacity of 208.0% and an encapsulation efficiency of 85.4%. In vitro drug delivery study indicated that the FA-conjugated microspheres could deliver Dox into MCF-7 cells more efficiently than the microspheres without functionalization of FA. Furthermore, WST-1 assay showed that the microspheres had no obvious toxicity to MCF-7 cells even at a high concentration of 2000 μg mL(-1). The resultant microsphere may be a promising vector for delivery of anti-cancer drugs as it exhibits a low cytotoxicity and degradability, precise molecular targeting property and multi-stimuli responsively controlled drug release.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP60984578	N,N′-Bis(acryloyl)cystamine		60984-57-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: