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Formaldehyde, Glyoxal, Urethane, Methyl Carbamate, 2,3-butanedione, 2,3-hexanedione, Ethyl Acrylate, Dibromoacetonitrile and 2-hydroxypropionitrile Induce Chromosome Loss in Saccharomyces Cerevisiae

Formaldehyde, Glyoxal, Urethane, Methyl Carbamate, 2,3-butanedione, 2,3-hexanedione, Ethyl Acrylate, Dibromoacetonitrile and 2-hydroxypropionitrile Induce Chromosome Loss in Saccharomyces Cerevisiae

F K Zimmermann, A Mohr

Mutat Res. 1992 Nov 16;270(2):151-66.

PMID: 1383732

Abstract:

Induction of mitotic chromosome loss could be demonstrated for the dialdehyde glyoxal, the diketones 2,3-butanedione and 2,3-hexanedione, ethyl and methyl carbamate, ethyl acrylate, dibromoacetonitrile, 2-hydroxypropionitrile and formaldehyde, but only when they were combined with subacute concentrations of propionitrile, which is a strong inducer of chromosomal malsegregation. The same chemicals did not induce mitotic chromosome loss when applied in pure form. However, glyoxal, ethyl acrylate, dibromoacetonitrile and formaldehyde when applied in pure form also induced mitotic recombination. Respiratory deficiency was induced, in the absence of propionitrile, by these recombinogenic agents and also by 2,3-hexanedione and 2-hydroxypropionitrile which are not recombinogenic.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3848246	2,3-Hexanedione		3848-24-6	Price

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