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Formaldehyde in "Nontoxic" Nail Polish

Formaldehyde in "Nontoxic" Nail Polish

Lindsey M Voller, Lena Persson, Magnus Bruze, Marna E Ericson, Sara A Hylwa

Dermatitis. Jul/Aug 2019;30(4):259-263.

PMID: 31261225

Abstract:

Background:
Nail polish is known to contain potentially hazardous chemicals that have been linked to adverse health effects after overexposure. Formaldehyde is used as an antimicrobial, preservative, and nail hardener in select nail products, yet it is a recognized carcinogen and potent allergen in allergic contact dermatitis.
Objective:
The aim of this study was to investigate whether formaldehyde is present in nail polishes marketed as formaldehyde-free.
Methods:
Twenty-nine cosmetic nail polishes were purchased for analysis; of these, 28 were advertised as formaldehyde-free and/or did not declare formaldehyde in their ingredient lists. Initial testing was pursued using the chromotropic acid method, which uses a red-purple color change to indicate the presence of formaldehyde. Products were subsequently analyzed at least twice using high-performance liquid chromatography, quantifying formaldehyde amount above the detection limit of 2 ppm.
Conclusions:
High-performance liquid chromatography analysis found 5 of 29 products containing formaldehyde, 4 of which were advertised as formaldehyde-free. All other products were negative for formaldehyde (<2 ppm). Further investigation is warranted among brands testing positive and whether multiple products within the same line contain formaldehyde. Nail products must be labeled appropriately to avoid adverse reactions among individuals with cutaneous sensitivities.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP86356732	Formaldehyde O-pentafluorophenylmethyl-oxime		86356-73-2	Price

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