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Formation of Extracellular Sphingolipids by Microorganisms: IV. Pilot-Plant Production of Tetraacetylphytosphingosine by Hansenula Ciferrii

H G Maister, S P Rogovin, F H Stodola, L J Wickerham

Appl Microbiol. 1962 Sep;10(5):401-6.

PMID: 16349621

Abstract:

Tetraacetylphytosphingosine (TAPS) formation by the F-60-10 mating type strain of the yeast Hansenula ciferrii, previously observed on agar plates, has been shown to take place in submerged cultures. The optimal conditions for TAPS formation, and the correlation of TAPS production and sugar utilization under aerobic conditions, were studied in 10-liter fermentors. For each gram of glucose consumed, 5 mg of TAPS were formed; for each gram of yeast solids produced, 15 mg of TAPS were synthesized. A 750-liter pilot-plant run yielded 175 g of crude TAPS, which were obtained by hexane extraction of centrifuged yeast cells.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP13018489 Tetraacetylphytosphingosine Tetraacetylphytosphingosine 13018-48-9 Price
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