Home
Resources
Publications
Formation of Reversible Shell Cross-Linked Micelles From the Biodegradable Amphiphilic Diblock Copolymer poly(L-cysteine)-block-poly(L-lactide)

Formation of Reversible Shell Cross-Linked Micelles From the Biodegradable Amphiphilic Diblock Copolymer poly(L-cysteine)-block-poly(L-lactide)

Jing Sun, Xuesi Chen, Tiancheng Lu, Shi Liu, Huayu Tian, Zhaopei Guo, Xiabin Jing

Langmuir. 2008 Sep 16;24(18):10099-106.

PMID: 18698858

Abstract:

A novel biodegradable diblock copolymer, poly(L-cysteine)-b-poly(L-lactide) (PLC-b-PLLA), was synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of beta-benzyloxycarbonyl-L-cysteine (ZLC-NCA) with amino-terminated poly(L-lactide) (NH 2-PLLA) as a macroinitiator in a convenient way. The diblock copolymer and its precursor were characterized by (1)H NMR, Fourier transform infrared (FT-IR), gel permeation chromatography (GPC), and X-ray photoelectron spectroscopy (XPS) measurements. The length of each block polymer could be tailored by molecular design and the ratios of feeding monomers. The cell adhesion and cell spread on the PZLC-b-PLLA and PLC-b-PLLA films were enhanced compared to those on pure PLA film. PLC-b-PLLA can self-assemble to form micelles in aqueous media. A pyrene probe is used to demonstrate the micelle formation of PLC-b-PLLA in aqueous solution. Due to the ease of disulfide exchange with thiols, the obtained micelles are reversible shell cross-linked (SCL) micelles. The morphology and size of the micelles are studied by dynamic light scattering (DLS) and environmental scanning electron microscopy (ESEM).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS71131	Poly(L-lactide) N-2-hydroxyethylmaleimide terminated			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: