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Formulation of Carbopol

Leire Ruiz-Rubio, María Luz Alonso, Leyre Pérez-Álvarez, Rosa Maria Alonso, Jose Luis Vilas, Vitaliy V Khutoryanskiy

Polymers (Basel). 2018 Feb 11;10(2):175.

PMID: 30966211

Abstract:

Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug, hydrocortisone, using interpolymer complexes and physical blends of poly(2-ethyl-2-oxazoline)s and two Carbopols® (Carbopol 974 and Carbopol 971) for oromucosal administration. The swelling, hydrocortisone release and mucoadhesive properties of a series of tablet formulations obtained by combination of different Carbopols with poly(2-ethyl-2-oxazoline)s of different molecular weights have been evaluated in vitro.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP92450992 O-[2-(3-Succinylamino)ethyl]-O′-methyl-polyethylene glycol O-[2-(3-Succinylamino)ethyl]-O′-methyl-polyethylene glycol 92450-99-2 Price
LS74609 Poly(2-ethyl-2-oxazoline) Poly(2-ethyl-2-oxazoline) Price
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