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[Foscarnet Sodium for Treatment in Patients With Severe Chronic Hepatitis B]

[Foscarnet Sodium for Treatment in Patients With Severe Chronic Hepatitis B]

Yan-yan Yu, Da-zhi Zhang, Xiao-hui Miao, Chuan-lin Zhu, Xia-qiu Zhou, Hao Yu, Chong-wen Si

Zhonghua Gan Zang Bing Za Zhi. 2006 Nov;14(11):814-6.

PMID: 17125606

Abstract:

Objective:
To investigate the effectiveness of foscarnet sodium in the treatment of severe chronic hepatitis B.
Methods:
Two hundred and eight patients were enrolled in a multicenter, double-blind, controlled study. The patients received foscarnet sodium (foscarnet group) or saline (control group) injections for 4 weeks, and were then followed for 24 weeks.
Results:
HBV DNA negative rate was 12.8% in the foscarnet group and 7.1% in the control group at the end of treatment; and it was 5.5% and 3.0% at the end of the follow-up period respectively (P > 0.05). The rate of HBV DNA decrease of more than 2 log copies/ml was 53.2% in the foscarnet group and 16.2% in the control group at the end of treatment, and 23.9% and 8.1% (P < 0.01) respectively at the end of the follow-up period. The rate of HBV DNA < 10(5) copies/ml was 64.2% and 30.3% at week 4 in the two groups respectively, and 40.4% and 22.2% (P < 0.01) at the end of the follow-up period. HBeAg negative rate was 17.3% and 5.8% at the end of the treatment, and 22% and 5.4% at the end of the follow-up period (P < 0.01). The rate of HBeAg seroconversion was 12.7% and 3.7% at week 4, and 16.7% and 1.5% at the end of the follow-up period. Response rate was 60.6% and 21.2% at the end of week 4 (P < 0.05).
Conclusion:
Foscarnet sodium injection has a good effect on severe chronic hepatitis B patients and it is safe to use on them.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP34156564	Foscarnet sodium		34156-56-4	Price

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