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Fosfomycin: Pharmacological, Clinical and Future Perspectives

Fosfomycin: Pharmacological, Clinical and Future Perspectives

Anneke Corinne Dijkmans, Natalia Veneranda Ortiz Zacarías, Jacobus Burggraaf, Johan Willem Mouton, Erik Bert Wilms, Cees van Nieuwkoop, Daniel Johannes Touw, Jasper Stevens, Ingrid Maria Catharina Kamerling

Antibiotics (Basel). 2017 Oct 31;6(4):24.

PMID: 29088073

Abstract:

Fosfomycin is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis. Evidence suggests that fosfomycin has a synergistic effect when used in combination with other antimicrobial agents that act via a different mechanism of action, thereby allowing for reduced dosages and lower toxicity. Fosfomycin does not bind to plasma proteins and is cleared via the kidneys. Due to its extensive tissue penetration, fosfomycin may be indicated for infections of the CNS, soft tissues, bone, lungs, and abscesses. The oral bioavailability of fosfomycin tromethamine is <50%; therefore, oral administration of fosfomycin tromethamine is approved only as a 3-gram one-time dose for treating urinary tract infections. However, based on published PK parameters, PK/PD simulations have been performed for several multiple-dose regimens, which might lead to the future use of fosfomycin for treating complicated infections with multidrug-resistant bacteria. Because essential pharmacological information and knowledge regarding mechanisms of resistance are currently limited and/or controversial, further studies are urgently needed, and fosfomycin monotherapy should be avoided.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP78964859	Fosfomycin tromethamine		78964-85-9	Price

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