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Fragrance Contact Dermatitis: A Worldwide Multicenter Investigation (Part II)

Fragrance Contact Dermatitis: A Worldwide Multicenter Investigation (Part II)

W Larsen, H Nakayama, T Fischer, P Elsner, P Frosch, D Burrows, W Jordan, S Shaw, J Wilkinson, J Marks Jr, M Sugawara, M Nethercott, J Nethercott

Contact Dermatitis. 2001 Jun;44(6):344-6.

PMID: 11380544

Abstract:

The purpose of this study was to determine the frequency of responses to selected fragrance materials in patients who were fragrance sensitive. 178 patients were evaluated in 8 centers worldwide with a fragrance mix (FM) and 20 other fragrance materials. Reaction to the fragrance mixture (FM) occurred in 78.7% of the subjects. Substances reacting at a rate of 2% or higher included jasmine absolute, geranium oil bourbon, l-citronellol, spearmint oil, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran, omega-6-hexadecenlactone, dimethyltetrahydrobenzaldehyde (isomer mixture), and alpha-amylcinnamaldehyde. These chemicals should be furthur evaluated to corroborate their allergenicity. We are constantly looking for new fragrance allergens to extend the diagnostic capability of the fragrance mix (FM).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP122407	α-Amylcinnamaldehyde		122-40-7	Price

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