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Fragrance Material Review on Phenethyl Acetate

Fragrance Material Review on Phenethyl Acetate

D McGinty, D Vitale, C S Letizia, A M Api

Food Chem Toxicol. 2012 Sep;50 Suppl 2:S491-7.

PMID: 22414644

Abstract:

A toxicologic and dermatologic review of phenethyl acetate when used as a fragrance ingredient is presented. Phenethyl acetate is a member of the fragrance structural group aryl alkyl alcohol simple acid esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for phenethyl acetate were evaluated, then summarized, and includes: physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, elicitation, toxicokinetics, repeated dose, genotoxicity, and carcinogenicity data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP103457	Phenethyl acetate		103-45-7	Price

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