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Fraxin Prevents Chemically Induced Hepatotoxicity by Reducing Oxidative Stress

Fraxin Prevents Chemically Induced Hepatotoxicity by Reducing Oxidative Stress

Bo Yoon Chang, Young Suk Jung, Chi-Su Yoon, Jun Seok Oh, Jae Heoi Hong, Youn-Chul Kim, Sung Yeon Kim

Molecules. 2017 Apr 6;22(4):587.

PMID: 28383514

Abstract:

Fraxin isolated from Acer tegmentosum is reported to exert potent anti-oxidative stress action. However, pharmacological activities of fraxin remain to be elucidated. This study investigated the potential hepatoprotective effects of fraxin and the underlying signaling mechanism involved. Treatment with fraxin significantly lowered the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a CCl₄-induced hepatotoxicity rat model. In the fraxin-treated group, glutathione (GSH) significantly increased, while the malondialdehyde (MDA) in the liver significantly decreased. Fraxin also showed radical-scavenging activity. Furthermore, it significantly reduced the t-BHP-induced cytotoxicity and production of reactive oxygen species (ROS) in Hep G2. Fraxin protected Hep G2 cells through Nrf2 pathway-dependent HO-1 expression. The results of this study indicate that fraxin shows potent hepatoprotective effects in vitro and in vivo, presumably through direct antioxidant activity and the Nrf2-mediated antioxidant enzyme system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP524301-A	Fraxin		524-30-1	Price

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