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From Rabbit Antibody Repertoires to Rabbit Monoclonal Antibodies

Justus Weber, Haiyong Peng, Christoph Rader

Exp Mol Med. 2017 Mar 24;49(3):e305.

PMID: 28336958

Abstract:

In this review, we explain why and how rabbit monoclonal antibodies have become outstanding reagents for laboratory research and increasingly for diagnostic and therapeutic applications. Starting with the unique ontogeny of rabbit B cells that affords highly distinctive antibody repertoires rich in in vivo pruned binders of high diversity, affinity and specificity, we describe the generation of rabbit monoclonal antibodies by hybridoma technology, phage display and alternative methods, along with an account of successful humanization strategies.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42413835 Anti-Rab9 from rabbit Anti-Rab9 from rabbit Price
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