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Fucoidan From Seaweed Fucus Vesiculosus Inhibits 2,4-dinitrochlorobenzene-induced Atopic Dermatitis

Fucoidan From Seaweed Fucus Vesiculosus Inhibits 2,4-dinitrochlorobenzene-induced Atopic Dermatitis

Tian Tian, Hao Chang, Kun He, Yangyue Ni, Chen Li, Min Hou, Lin Chen, Zhipeng Xu, Bin Chen, Minjun Ji

Int Immunopharmacol. 2019 Oct;75:105823.

PMID: 31422184

Abstract:

Fucoidan, one activator of scavenger receptor class A (SR-A), plays important roles in a variety of biological activities, including anti-inflammatory, antioxidant, and antitumor actions. However, the effects of fucoidan on atopic dermatitis (AD) have not been elucidated. To assess this, 2,4-dinitrofluorobenzene (DNFB)-treated BALB/c mice were painted with fucoidan. Results showed that fucoidan significantly ameliorated ear swelling, improved abdomen skin lesions, and decreased inflammatory cell infiltration. In addition, fucoidan significantly suppressed the serum levels of IgE and IL-4 in DNFB-induced AD mice. The infiltration of CD4+ T cells in skin lesions and spleen was also reduced in fucoidan-treated AD mice. Furthermore, treatment with fucoidan promoted Treg cells but attenuated Th1/17 response in the spleens from DNFB-induced AD mice. Together, these results suggest that fucoidan, a natural seaweed-rich polysaccharide, has a potential therapeutic efficacy in the treatment of AD, correlates with the induction of higher anti-inflammatory response through inducing Treg cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9072199-A	Fucoidan from Fucus vesiculosus		9072-19-9	Price

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