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Fumitremorgin C Reverses Multidrug Resistance in Cells Transfected With the Breast Cancer Resistance Protein

Fumitremorgin C Reverses Multidrug Resistance in Cells Transfected With the Breast Cancer Resistance Protein

S K Rabindran, D D Ross, L A Doyle, W Yang, L M Greenberger

Cancer Res. 2000 Jan 1;60(1):47-50.

PMID: 10646850

Abstract:

Fumitremorgin C (FTC) is a potent and specific chemosensitizing agent in cell lines selected for resistance to mitoxantrone that do not overexpress P-glycoprotein or multidrug resistance protein. The gene encoding a novel transporter, the breast cancer resistance protein (BCRP), was recently found to be overexpressed in a mitoxantrone-selected human colon cell line, S1-M1-3.2, which was used to identify FTC. Because the drug-selected cell line may contain multiple alterations contributing to the multidrug resistance phenotype, we examined the effect of FTC on MCF-7 cells transfected with the BCRP gene. We report that FTC almost completely reverses resistance mediated by BCRP in vitro and is a pharmacological probe for the expression and molecular action of this transporter.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP118974020	Fumitremorgin C		118974-02-0	Price

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